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Bio B2BCHO Pharma Inc. 〉Glycan arrays and glycoprobes

Glycan arrays and glycoprobes

Glycan arrays and glycoprobes

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Overview
Synthetic oligosaccharides and/or polysaccharides are immobilized on a solid supported in a spatially-defined arrangement to mimic the glycan expression on cell surface. The arrays of various glycans can be used for the diagnosis and prognosis of the disease such as cancer and infectious disease. They can also be used as research tools such as the validation of glycan binding protein and antibody, and binding affinity determination.
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Chemoenzymatic synthesis approach is utilized to produce library of human oligosaccharides and polysaccharides. The synthesized glycans are immobilized on the patented aluminum oxide-coated glass slides. Over 10 folds of detection sensitivity of the glycan array is enhanced by using this unique slide-coating technology. The high sensitivity of the arrays fulfill the critical requirement of the clinical diagnostic tools.
The global market of biological arrays has grown significantly in the past few years. Although the alterations in glycan profiles have been associated with a variety of diseases, the applications of glycan arrays in diagnostics is still at infancy stage mainly due to its relatively high technology barrier. With the extensive experience in glycan synthesis and slide-coating technology, our glycan array has the great potential to become the leader in the field.
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