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FB825

FB825

A humanized anti-CεmX monoclonal antibody

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Overview
FB825 is a humanized monoclonal antibody that binds to the CεmX domain, leading to death of the membrane IgE+ B lymphocytes by inducing apoptosis and antibody-dependent cellular cytotoxicity (ADCC) in a dosing-dependent manner. FB825 can stand alone as a monotherapy or in combination with Xolair for the treatment of allergic asthma and IgE-mediated diseases. 

FB825 has a long-lasting effect in down-regulating IgE production. Therefore, it may also have a potential to replace Xolair in the future.
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