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Bio B2BCaduceus Biotechnology Inc. 〉Dynamic Auto-Focusing

Dynamic Auto-Focusing

Dynamic Auto-Focusing

Dynamic Auto-FocusingProblematic laser focusing maybe resulted from the exclusive changes in the glass slide. That will come with suspicious data by over/under focus.

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Overview
The laser beams are dynamically focused on the surface of microarray slide based on the auto-focusing function using the focus error signal (FES). The auto-focusing of the laser beam is controlled using the focusing voice coil motor (VCM) to adjust the vertical distance between the objective lens and the surface of the sample slide on the basis of the FES (= (A+C)−(B+D), where A, B, C, and D are the intensities of the four divided regions of photodetector).
Application
SpinScan Microarray Scanner is an open system for most of biochips including Cell, protein, DNA and peptide chips, therefore, it could be used for various kinds of diagnostics.

For Human
  • Allergy test
  • Prenatal Diagnosis
  • Chromosomal aberrations in fetal and neonatal genomes
  • Serum Biomarker Discovery
  • Detection of antigen/antibody in blood
  • Diagnostics for different stages of cancer
  • Identify infectious diseases & neurological disease
For Veterinary
  • Gene expression analysis for veterinary pathologists
  • Total IgE quantitative test for canine
  • Allergens(IgE) screening test
For Agriculture
  • Detection of plant pathogens and gene expression​
  • Screening and evaluation of herbal plants and herbal dietary supplements
  • Analysis of drug-metabolizing genes
Patent Portfolio
Publications
 
Rung-Ywan Tsai*, Jung-Po Chen, Yuan-Chin Lee, Hung-Chih Chiang, Tai-Ting Huang, Chun-Chieh Huang, Chih-Ming Cheng, Chung-Ta Cheng, Feng-Hsiang Lo, Golden Tiao, “Resolution enhancement of digital laser scanning fluorescence microscopy with a dual-lens optical pickup head”, Optical Review, 23, 817-823 (2016).
 
Rung-Ywan Tsai*, Jung-Po Chen, Yuan-Chin Lee, Hung-Chih Chiang, Chih-Ming Cheng, Chun-Chieh Huang, Tai-Ting Huang, Chung-Ta Cheng, and Golden Tiao, “Cell depth imaging by point laser scanning fluorescence microscopy with an optical disk pickup head”, Jpn. J. Appl. Phys. 54, 09MD01-06 (2015).
 
Rung-Ywan Tsai*, Jung-Po Chen, Yuan-Chin Lee, Chun-Chieh Huang, Tai-Ting Huang, Hung-Chih Chiang, Chih-Ming Cheng, Feng-Hsiang Lo, Sheng-Li Chang, Kuo-Yao Weng, Lung-Pin Chung, Jyh-Chern Chen, and Golden Tiao, “Position-addressable digital laser scanning point fluorescence microscopy with a Blu-ray disk pickup head”, Biomed. Opt. Exp., 5, 427-438 (2014).
 
Conference

Rung-Ywan Tsai, Jung-Po Chen, Feng-Hsiang Lo, Chien Chung Pien, Jean-Dow Lee, Jinn-Cherng Yang, Kuang Wu Hsu, Golden Tiao, “SpinScan Microarray Scanner Based on a Modified Optical Pickup Head,” ODF ‘18, Hiroshima, Japan, Nov.  28-30 (2018). (Oral Presentation)

Rung-Ywan Tsai, J.P. Chen, F.H. Lo, C.C. Pien, J.D. Lee, J.C. Yang, K.W. Hsu, G. Tiao, “High Resolution Microarray Fluorescence Scanner” 2018 International Conference on Smart Sensors and 21st Nano Engineering and Microsystem Technology Conference, Taipei, Taiwan, June 1-2 (2018)

Po-Wei Hu, Hsien-Lung Ho, Rung-Ywan Tsai and Fan-Gang Tseng, “An Electrically Tunable Asymmetrical Liquid Lens System for Optical Coherent Tomography,” The 10th International Meeting on Electrowetting 2016, Taipei, Taiwan, June 19-22 (2016). (Best Poster Award)
 
Rung-Ywan Tsai, Jung-Po Chen, Yuan-Chin Lee, Chun-Chieh Huang, Hung-Chih Chiang, Chih-Ming Cheng, Chung-Ta Cheng, Chih-Ming Cheng, Jin-Chen Yang, and Golden Tiao, “Laser Scanning Applications Based on an Optical Pickup Head Technology”, ODF ‘16, Hochschule Ravensburg-WeinGarten, Germany, February 29-March 2 (2016). (Invited Talk)
 
Rung-Ywan Tsai, Jung-Po Chen, Yuan-Chin Lee, Hung-Chih Chiang, Tai-Ting Huang, Chun-Chieh Huang, Chih-Ming Cheng, Chung-Ta Cheng, Feng-Hsiung Lo, and Golden Tiao, “Image Resolution Enhancement of Digital Laser Scanning Fluorescence Microscopy with a Dual-Lens Optical Pickup Head”, Hochschule Ravensburg-WeinGarten, Germany, February 29-March 2 (2016).

Patent

"Microarray Wafer and Cell Analysis Method Using Same" US62/822,033
"Label-free Micro- and Nano-Array biochips" US15/823,610
"Dynamic Focusing Confocal Optical Scanner" US15/441,251
"Optical Biochip Scanner" US62/351,281
"Optical Equipment and Registration Method" US8,514,390
Collaboration Options
What we are looking for?
  • Biochip manufacturers
Co-brand for chip/scanner integrated service
Fully support on service/maintenance by us
  • End Users
Hospitals/labs/Academy
  • Distributors
Representative in local market
Assist with local registration/license
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